Soon after 1600, with the area mostly united under one native ruler, native tribesmen began encountering, trading with and making alliances with Portuguese traders and members of the military. By 1700, however, the empire had broken up into areas controlled by many individual ethnic groups. The Arab slave trade reached its height in the mid- 1800s, when approximately 20,000 people were enslaved and considered to be carried yearly from Nkhotakota to Kilwa where they were sold.
Missionary and explorer David Livingstone reached Lake Malawi (then Lake Nyasa) in 1859 and identified the Shire Highlands south of the lake as an area suitable for European settlement. As the result of Livingstone’s visit, several Anglican and Presbyterian missions were established in the area in the 1860s and 1870s, the African Lakes Company Limited was established in 1878 to set up a trade and transport concern working closely with the missions, and a small mission and trading settlement was established at Blantyre in 1876 and a British Consul took up residence there in 1883. The Portuguese government was also interested in the area so, to prevent Portuguese occupation, the British government sent Harry Johnston as British consul with instructions to make treaties with local rulers beyond Portuguese jurisdiction.
In 1889, a British protectorate was proclaimed over the Shire Highlands, which was extended in 1891 to include the whole of present-day Malawi as the British Central Africa Protectorate. In 1907, the protectorate was renamed Nyasaland, a name it retained for the remainder of its time under British rule. In a prime example of what is sometimes called the “Thin White Line” of colonial authority in Africa, the colonial government of Nyasaland was formed in 1891. The administrators were given a budget of £10,000 (1891 nominal value) per year, which was enough to employ ten European civilians, two military officers, seventy Punjab Sikhs and eighty-five Zanzibar porters. These few employees were then expected to administer and police a territory of around 94,000 square kilometers with between one and two million people.
In 1944, the Nyasaland African Congress (NAC) was formed by the Africans of Nyasaland to promote local interests to the British government. In 1953, Britain linked Nyasaland with Northern and Southern Rhodesia in what was the Federation of Rhodesia and Nyasaland, often called the Central African Federation (CAF), for mainly political reasons. Even though the Federation was semi-independent, the linking provoked opposition from African nationalists, and the NAC gained popular support. An influential opponent of the CAF was Hastings Banda, a European-trained doctor working in Ghana who was persuaded to return to Nyasaland in 1958 to assist the nationalist cause. Banda was elected president of the NAC and worked to mobilise nationalist sentiment before being jailed by colonial authorities in 1959. He was released in 1960 and asked to help draft a new constitution for Nyasaland, with a clause granting Africans the majority in the colony’s Legislative Council.